The University of Texas - MD Anderson Cancer Center (UT-MDACC) strives to eliminate cancer in Texas, the United States, and the World by implementing outstanding programs that integrate patient care, research, and prevention, as well as by educating undergraduate and graduate students, trainees, professionals, employees, and the general public.

　　The Therapeutics Discovery Division (TDD) at MD Anderson Cancer Center is a potent engine driving the future of innovative targeted, immune-, and cell-based medicines. Therapeutics Discovery reduces bottlenecks in traditional drug discovery by bringing together a diverse team of committed researchers, clinicians, drug developers, and scientific experts to develop small-molecule therapeutics, biologics, and cellular therapies. Our innovative structure and collaborative approach enable the team to work swiftly and efficiently, bringing breakthrough medications from concept to clinic - all under one roof. The Therapeutics Discovery Division is organized around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium (NDC).

　　The goal of the ORBIT Platform is to make MDACC a recognized leader in the discovery and development of novel biologics that help patients overcome cancer. ORBIT is a centralized MDACC entity tasked with guiding, informing, accelerating, and carrying out the innovative discoveries into clinically useful cancer bio-therapeutics. We are committed to biologics development that meets industrial standards, with the goal of integrating scientific quality with commercialization.

　　We are looking for an enthusiastic Institute Associate II to join our team in the research and development of innovative anti-cancer biologics. Applicant will participate in cross-functional research to identify and evaluate novel cancer targets, with the goal of translating these discoveries into oncology therapeutic medicines that will help patients. The ideal candidate will be an experienced researcher with expertise in protein characterization and/or molecular biology. The position requires a highly motivated self-starter with exceptional organizational skills who can effectively deliver results and conclusions to coworkers, collaborators, and the management. It is crucial to be able to function in a team-based environment where attaining team goals defines success. Candidates with experience in monoclonal antibody biophysical and biochemical characterization, as well as molecular biology, will be given preference.

　　Key Functions:

　　Under moderate supervision, conduct laboratory experiments on antibody expression and characterization to support antibody lead discovery for therapeutic drug discovery projects.

　　Assist in establishing, conducting, and validating experiments, studies and/or research models.

　　Assist in antibody discovery campaigns utilizing hybridoma technology, including memory B and plasma cell enrichment, hybridoma electrofusion, high-throughput screening, and clonal selection and expansion.

　　Purification of recombinant proteins and antibodies using AKTA chromatography system by affinity, size exclusion, and ion-exchange methods

　　Perform antibody characterization including HPLC-SEC, UV, SDS-PAGE, Western blotting, and LC-MS assays.

　　Development, execution, and interpretation of various cell-based and biochemical assays for monoclonal antibody screening and characterization (binding, blocking, ADCC, and ADCP).

　　Generation, characterization, and maintenance of cell lines for the development of novel reporter-based bioassays for Ab functional screening and mechanism of action studies.

　　Under minimal supervision, design, creation, and construction of vectors for recombinant protein and antibody discovery.

　　Under supervision, design, optimization, and implementation of RT-PCR from single cells.

　　Analyze and mine DNA sequences from Sanger and NGS for sequence activity relationships to enable affinity maturation of antibodies.

　　Perform DNA mini-, midi-, maxi-prepping procedures, and maintain and archive DNA clones, and bacterial glycerol stocks.

　　Execute standard protocols and assist in developing novel experimental procedures.

　　Record and evaluate data in accordance with methods requested and presents data to the research project.

　　Employ safe lab practices.

　　Skills:

　　Excellent written and verbal communication skills are must.

　　Strong organizational skills are necessary.

　　Demonstrated creativity and novel approaches to solve scientific problems is preferred.

　　Excellent interpersonal skills and the ability to interact with others are necessary.

　　Detail-oriented with excellent record-keeping skills is required.

　　The ability to properly present scientific data and concepts is a must.

　　EDUCATION:

　　Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

　　Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

　　EXPERIENCE:

　　Required: One year of relevant research experience in lab. With preferred degree, no required experience.

　　Preferred: Molecular cloning, protein biophysical and biochemical characterization and antibody-antigen interaction analysis, molecular biology, protein expression, purification, and characterization with state-of-the-art techniques

　　It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

　　Additional Information

　　Requisition ID: 164868

　　Employment Status: Full-Time

　　Employee Status: Regular

　　Work Week: Days

　　Minimum Salary: US Dollar (USD) 64,875

　　Midpoint Salary: US Dollar (USD) 82,500

　　Maximum Salary : US Dollar (USD) 97,400

　　FLSA: exempt and not eligible for overtime pay

　　Fund Type: Soft

　　Work Location: Onsite

　　Pivotal Position: Yes

　　Referral Bonus Available?: Yes

　　Relocation Assistance Available?: Yes

　　Science Jobs: Yes

　　#LI-Onsite