PostedJanuary 04, 2024POST-DOCTORAL SCIENTISTEditing of the CFTR locus: the impact on chromatin architectureand gene expressionDepartment of Genetics and Genome SciencesCase Western Reserve UniversityCleveland, Ohio. USAThe goals of this collaborative research program are to repair mutations in the cysticfibrosis transmembrane conductance regulator (CFTR) gene, by gene editing.Errors in CFTR are associated with the common inherited disorder cystic fibrosis. CFTRhas a complex pattern of tissue specific and temporal regulation. The project will involve1) Definition of CFTR regulatory mechanisms in orphan tissues.2) CRISPR/Cas9 protocols to manipulate CFTR gene expression.3) Analysis of the impact of therapeutic gene editing on CFTR locus architectureand gene expression.Successful applicants for this CFF funded program will have a strong record ofaccomplishment as shown by publications as a graduate student and/or postdoc, behighly motivated and have a passion for functional genomics research.Expertise in molecular biology protocols is essential. Familiarity with general techniquesof functional genomics and mammalian cell biology is preferred. We are part of a vibrantand interactive research community at Case Western Reserve University and occupyexcellent, modern laboratory space.Please send an electronic letter of application, quoting the reference CWRU/AH1/2024,Curriculum Vitae and contact information of 3 referees to: [email protected]. Hiring iscontingent upon eligibility to work in the United States.DIVERSITY STATEMENT:In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.REASONABLE ACCOMMODATIONS:Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-casebasis.Case Western Reserve University strives to maintain a diverse and inclusive work environment. All applicants are protected under Federal law from discrimination based on race, color, religion, sex, national origin, disability, age and genetics.