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　　rPostdoc/Assistant Staff Scientist - Lupus

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　　rOverview

　　rOMRF is an independent, not-for-profit biomedical research instituteadjacent to the University of Oklahoma Health Sciences Center (OUHSC)campus in Oklahoma City. Oklahoma City offers a dynamic and flourishingdowntown area, with low cost of living, short commute times and adiversified economy.

　　OMRF\'s excellence can only be fully realized by individuals who shareour commitment to diversity, equity and inclusion. Successful candidateswill demonstrate commitment to these values. OMRF is an EqualOpportunity/Affirmative Action Employer. All qualified applicants willreceive consideration for employment without regard to gender, sexualorientation, gender identity, race, color, national origin, age,religion, disability, veteran status or any other legally protectedcharacteristic.

　　Benefits

　　We offer competitive salaries and comprehensive benefits including,medical, dental, and vision insurance, minimum 8% company retirementcontribution, vacation and sick leave, paid holidays, onsite cafe, freeonsite fitness center with access to personal trainer, free parking andmuch more! Relocation assistance available for those located 50 milesoutside of Oklahoma City metro and out of state. Learn more about ourbenefitshere{target="_blank"rel="noopener"}.

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　　rResponsibilities

　　rThe NathLab{target="_blank"rel="noopener"} is seeking a highly motivated, hardworking and organizedteam player (Post-doctoral Fellow / Assistant Staff Scientist) to joinour effort to understand genetic mechanisms of lupus, an autoimmunedisease. Using whole genome search, our lab has identified severalgenes/genetic variants, associated with lupus susceptibility. Now we aretrying to understand the specific functional effects of those lupusassociated genetic variants, using cell lines, patients-derived primaryimmune cells or tissues. We will apply various modern techniques forstudying features of three-dimensional (3D) genomic organization such as3C, Hi-C, ChIP-Seq, and genome editing using CRISPR/Cas9. Candidate willbe involved in the analysis of human genetic data and the development ofcomputational methods, which requires a mix of computational skills,statistical knowledge, creativity and biological insight. Specifically,candidate will identify novel therapeutic targets and biomarkers fromthe investigation of human genetic variation (GWAS, Next Gen Sequencing)with disease status and intermediate variables using cutting-edgetechniques in Statistical Genetics. Candidate will develop and applymethods for the integration of GWAS summary results with other types ofdata e.g. eQTL, mQTL, functional genomic annotations, gene networks,estimation/partitioning of heritability, Mendelian Randomization tounderstand causal direction, and fine mapping. Candidate willcollaborate with experimental and clinical scientists to address targetmechanism specific questions and seek to support investment decisionmaking with genomic insights.

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　　rQualifications

　　rrrrPh.D. in a biological science or other relevant area, M.D., orequivalent.Knowledge of statistical genetic methods for gene-mapping forcomplex traits, and computer programming skills (e.g. familiarity withUNIX-like OS, and at least one programming language) are required.rrrr

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　　rTo apply, visithttps://careers-omrf.icims.com/jobs/1058/post-doctoral-fellow/job?in_iframe=1

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　　rOMRFs excellence can only be fully realized by individuals who share our commitment to diversity, equity and inclusion. Successful candidateswill demonstrate commitment to these values. OMRF is an EqualOpportunity/Affirmative Action Employer. All qualified applicants willreceive consideration for employment without regard to gender, sexualorientation, gender identity, race, color, national origin, age,religion, disability, veteran status or any other legally protectedcharacteristic.r

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