Reference #: 378339Site Name: USA - Pennsylvania - Upper Providence, USA - Florida - Tampa, USA - Georgia - Atlanta, USA - Illinois - Chicago, USA - Maryland - Baltimore, USA - New York - Albany, USA - New York - Buffalo, USA - Ohio - Cleveland, USA - Ohio - Columbus , USA - Pennsylvania - Pittsburgh, USA - Texas - Dallas, USA - Texas - Houston, Washington DCPosted Date: Nov 14 2023

　　The Department of Clinical Pharmacology Modeling and Simulation (CPMS) at GlaxoSmithKline (GSK) is recruiting for a Director-level quantitative clinical pharmacologist.  Locations include Collegeville, PA, Durham, NC, Cambridge, MA in the U.S. or Stevenage in the U.K.. Remote working may be considered for the right candidate.

　　This position represents a key opportunity for professionals with PhD, MD, PharmD or equivalent doctoral background, who are experienced clinical pharmacologists and pharmacometricians to advance the vision and mission of GSK's rapidly expanding Infectious Disease portfolio including vaccines to prevent, treat and cure infectious diseases.  Sought after experiences for this position include building and integrating mechanistic mathematical models and disease platforms with advanced analytical techniques (such as machine learning) to enhance the robustness and quality of decision-making from exploratory research, clinical development, registration and life cycle management.

　　You will be expected to play a critical role in driving integration of end-to-end model-informed drug discovery and development. In addition, you will be accountable to define, coordinate and defend Clinical Pharmacology Modelling & Simulation development strategies for disease & therapeutics of interest at senior level meetings, and provide expert input into the clinical pharmacology evidence generation and integrated evidence plans.  CPMS responsibilities and accountabilities generally commence at candidate selection with preparations of first time in human trials, and continue through to filing, registration, and market expansion.

　　Main responsibilities and accountabilities also include:

　　Establish or guide mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct meta-analyses as appropriate to generate knowledge through data re-use; conduct simulations to assess trial design performanceDefine and execute a co-ordinated scientific and technical strategy (18-24 months planning horizon) with demonstrated ability to co-ordinate outputs from several expertise areas to determine strategyBuild and utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalitiesWork in close collaboration with bench biologists, data scientists, computational biologists, clinicians and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanismsDevelop and/or utilize state-of-the-art mathematical tools to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interactionCreate a collaboration framework with internal and external experts in the development and application of these modelsLearn and apply emerging modeling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; collaborate with external field-leading teams for methodology applicationImplement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipelineAbility to interact with line and middle management, staff and external contacts on a functional, strategic and tactical levelRepresent CPMS on various internal advisory boards, companywide initiatives and/or leadership eamsPromote transparency and communicate R&D achievements through publications in appropriate scientific journals

　　Why you?

　　Basic Qualifications:

　　We are looking for a professional with these required skills to achieve our goals:PhD, MD, or PharmD with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and developmentFive or more years of experience in mechanistic mathematical modeling to apply to clinical questions in drug developmentFive or more years of experience in clinical pharmacokinetics, modelling/simulation and drug development to solve practical problems in pharmaceutical industry

　　Preferred Qualifications:Strong drive and learning agility to build knowledge on a drug-disease system, symptom progression, standard of care, and trial designDemonstrated aptitude for productive collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of resultsClear evidence of ability to make sound judgement in complex situations and adapt to changing business needs by prioritizing multiple tasksExperience working with senior stakeholders in a cross functional environmentStrong track record of implementation of Model-Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugsWhy GSK?

　　We're combining the power of genetic and genomic insights into what causes disease, with the speed and scaleof artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment mightwork for, and why. We believe this powerful combination of data and technology holds the key to fundamentallytransforming medical discovery for the better, improving R&D success rates and shaping how even the mostchallenging diseases, like neurological conditions and cancer, can be both prevented and treated.

　　In 2021 we delivered four major product approvals:Cabenuvafor HIV,Jemperlifor endometrial cancer,Xevudyfor COVID-19 andApretude, our new long-acting medicine for HIV prevention.

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　　Why Us?GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

　　Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

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