PNRI is recruiting a Staff Scientist to play a key leadership role in the Decoding Stress project based in the Stubbs Lab.  This project, initiated as a collaboration that integrated novel computational methods developed by Dr. David Galas and basic science mechanistic studies in the Stubbs group, is focused on uncovering the genetic mechanisms of stress-related health disorders with particular focus on how brain stress responses may contribute to comorbid disorders of metabolic and mental health.  The project aims to identify genetic alleles associated with disease susceptibility or resilience in clinical populations, including the search for genetic modifiers that can alter the effects of the primary alleles. Novel candidate genes and interactions will then be validated in mouse models, with mechanistic and functional insights developed at the genetic, genomic, cellular, and molecular levels. Ultimately, the project will identify novel loci and molecular pathways that can be used as translational targets for improving diagnostic applications or therapeutic outcomes in humans. 

　　The ideal candidate will have a vision for helping build a new multidisciplinary program leveraging insights from basic science and computational biology for the development of real world clinical/translational impact. We seek a highly motivated, energetic individual who can bring additional expertise in human genetics/clinical genetics, stress biology, and translational research methods into the team. The Staff Scientist will use their knowledge of human genetics and stress biology to help guide the identification of genes and gene networks in collaboration with the other team members.  The Staff Scientist will also lay the foundation for future clinical work by establishing external relationships with potential collaborators that have access to relevant clinical populations.  As a member of the project team, the Staff Scientist will actively contribute to scientific publications and the pursuit of funding opportunities.  For early career candidates, this is an opportunity for mentorship in scientific leadership and project management skills in a supportive, collaborative, and flexible professional environment.

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　　What you will do:

　　To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

　　Design, develop, implement, and execute scientific research for the Decoding Stress study under supervision of the Principal Investigator.In collaboration with the Principal Investigator, lay the foundation for future clinical work by establishing external relationships with potential collaborators with access to relevant clinical populations.Contribute to scientific publications, conferences, and the pursuit of funding opportunities.Maintain substantial knowledge of current scientific principles and theories relevant to the Decoding Stress project.Perform periodical/literature searches in preparation for study design.Participate in the analysis and interpretation of study data.Develop and implement research methodologies, instrumentation, and procedures.```{=html}

　　```- May coordinate activities of staff engaged on the Decoding Stress

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　　What you bring:

　　To perform this job successfully, an individual should be able to demonstrate the requirements listed below which are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

　　Doctoral degree (Ph.D., M.D. or equivalent) with post-graduate work experience relevant to the aims of the Decoding Stress project is required.