Employment Type: Permanent Staff (EHRA NF)

　　Vacancy ID: NF0007748

　　Position Summary/Description:

　　The primary purpose of this position is to serve as Research Specialist and laboratory manager in the laboratory of Dr. Karen Mohlke. This laboratory studies human genetic susceptibility to type 2 diabetes, obesity, dyslipidemia, and related quantitative traits. The Research Specialist will perform research using molecular and cellular biology approaches to test the molecular and biological consequences of human genetic variants associated with common, complex metabolic traits. The Research Specialist will be responsible for maintenance of a safe and efficient laboratory environment, including updating the lab safety plan and ensuring that lab members are safely trained in new procedures. The Research Specialist will maintain laboratory resources, including supplies, chemicals, equipment, and facilities and identify new supplies and equipment to increase efficiency of lab activities. The selected candidate will work with lab members and collaborators and train other researchers, including technical staff, postdoctoral fellows, graduate students, undergraduate students and others. Research activities will include molecular genetic assays and analyses such as PCR , cloning using bacterial and viral vectors, mutagenesis, measurement of RNA and protein levels, mammalian cell culture, tissue processing, sequencing library preparation, chromatin analysis, basic statistical analyses, and bioinformatic analyses using human genome resources. The Research Specialist will develop and improve CRISPR -based genome editing methods in the laboratory, including prime editing and implementation of multi-plexed high-throughput genome editing screens and assays.

　　Education and Experience:

　　B.S. in Genetics, Cell and Molecular biology, or a related field

　　Eight years experience in a research laboratory using standard molecular biology techniques and tissue culture

　　Ability to use the research literature to design detailed experimental methods, procedures, and/or techniques

　　AA/EEO Statement:

　　The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.