Reference #: 1006673SHIFT:Day (United States of America)

　　Seeking Breakthrough Makers

　　Children's Hospital of Philadelphia (CHOP)-named America's 2022 Best Large Employer by Forbes-offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

　　At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.

　　CHOP's Commitment to Diversity, Equity, and Inclusion

　　CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

　　We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

　　A Brief OverviewWill, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

　　A postdoctoral position is available for studying mechanisms of skeletal development, metabolism and repair at The Children's Hospital of Philadelphia (CHOP). The lab seeks to elucidate the molecular characteristics and fate determination of mesenchymal stem and progenitor cells in bone, and to understand the role of cellular and systemic metabolism in skeletal health and diseases. The experimental techniques include transcriptomic or epigenomic profiling by high throughout sequencing, molecular biology, mouse genetics and quantitative metabolic assays. The researcher will have access to first-rate core facilities both at CHOP and University of Pennsylvania, and enjoy interactions with experts in the fields of skeletal biology and metabolism at both institutions. An ideal candidate should have PhD or equivalent research experience in cell, molecular or developmental biology with a strong motivation for musculoskeletal research.

　　Current research topics include the following.-Skeletal stem and progenitor cells: The human skeleton is built and maintained by stem and progenitor cells but the identity, location, and control of those cells in the body remain incompletely understood. Ongoing projects aim to track and manipulate those cells genetically by using scRNA-seq and lineage-tracing techniques in animal models.

　　-Bone metabolism in type I or type II diabetes: Both juvenile and adult diabetes are associated with increased bone fractures. Current studies are uncovering the cellular and molecular basis for the bone frailty in diabetic mouse models, with the goal of discovering new therapeutic targets.

　　-Skeletal aging: Osteoarthritis and osteoporosis are commonly related with aging, but current treatm nts are inadequate. Current projects are exploring the connection between changes in cellular metabolism and skeletal health during aging.

　　Additional information is available on websites:

　　Please direct inquiry or application to Professor Fanxin Long, [email protected].

　　What you will doConduct independent scholarly research and develop new methods and protocolsParticipate in project planning, recording and evaluation of dataAcquire technical, lab management and grant writing skillsParticipate in seminars, lectures, poster sessions and presentation at national meetingsSupervise junior lab membersAssist with other research projectsEducation QualificationsDoctorate Required

　　To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, professionals working onsite-at any CHOP location, for any portion of time-must be vaccinated for COVID-19.

　　CHOP also requires employees who work in patient care buildings to receive an annual influenza vaccine. Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

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　　Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.