Reference #: 1005319SHIFT:Day (United States of America)

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　　A Brief OverviewPost Doctoral Fellow position in The Kalish Lab. The Kalish Lab studies how genetic and epigenetic alterations lead to overgrowth syndromes. This work focuses largely on patients with Beckwith-Wiedemann syndrome (BWS) and understanding the transition from normal growth to overgrowth to tumor formation. BWS is the most common cancer predisposition and growth disorder that leads to cancer in children. Children with BWS can develop overgrowth of a number of different organs and in some cases develop tumors, most commonly hepatoblastoma (liver cancer) and/or Wilms tumor (kidney cancer). Some of the same genetic and epigenetic changes that cause BWS are also seen in other types of cancer; therefore studying BWS is a window into understanding the larger questions about growth and the transition to cancer.

　　The Kalish Lab focuses on improving clinical care for children with BWS through clinical and translational research. The lab oversees the BWS registry and biorepository and its work uses clinical data and samples to understand the transition between normal growth, overgrowth, and cancer.The lab's clinical research focuses on improving care for the clinical features of BWS and understanding the correlations between those manifestations. Through this work the lab continues to develop national management guidelines for BWS. Its translational research focuses on how the epigenetic and genetic changes lead to the features of BWS including overgrowth and cancer, with goals of understanding these mechanisms and developing therapeutics.

　　The postdoctoral fellow will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project.The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

　　Dr. Kalish is seeking a postdoc with a strong microbiology background- this is a must.

　　Experience in: if you have this experience, please list this in your CVRNASequencingExperience in human pluripoten stem cell culture

　　Good writing is crucial to successfully conveying the importance of your research findings. You'll likely spend a good deal of time preparing papers, grant applications, reviews, and presentations, so be sure to sharpen your writing skills- we are seeking a post-doc who has written a manuscript.

　　salary information below:Years of Experience0=$65,0001=$65,5002=$66,0003=$66,5004=$67,000

　　Resumes can also be sent

　　To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine.

　　Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

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　　Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.