Position SummaryThe selected candidate will work with members in the Kuo lab to perform drug discovery and disease mechanism studies of Alzheimer's disease. Responsibilities include preparing recombinant proteins for in vitro and animal (mouse) studies. Experiments include, but not limited to, protein aggregation assays, cell viability quantification, mouse primary neuron isolation, mouse intracerebral injection and behavioral analysis, and immunohistological examination of mouse brain sections.

　　Detailed description of work/duties:

　　Apply, develop and execute strategies in induction and purification of high-quality hyperphosphorylated tau protein in E. coliAnalyze the cytotoxicity and neurotoxicity of hyperphosphorylated tau in vitro and in vivo Work closely with other project team members in tests of synthetic compounds for their efficacy in ameliorating the neurotoxicity of tauParticipate in brainstorming activities in support of the research  Work cross-functionally with faculty collaborators, postdocs, and graduate students at MSU and other institutesAssist in the preparation of formal reports to project team, patents, publications, and project planning

　　Equal Employment Opportunity StatementAll qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.

　　Required DegreeDoctorate -Biochemistry, Cell and Molecular Biology

　　Minimum RequirementsPhD in biochemistry, cell and molecular biology, neuroscience, or animal science

　　Desired Qualifications0 -- 3 years of postdoctoral experience on related fieldSound knowledge of animal treatment and examinationExcellent working knowledge of recombinant protein preparation and characterizationExcellent interpersonal, communication and writing skills

　　Required Application MaterialsCover letter

　　CV

　　Review of Applications Begins On11/01/2023

　　Websitehttps://bmb.natsci.msu.edu/

　　MSU StatementMichigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.