Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position will be located at the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

　　LINE-1 retrotransposons and endogenous retroviruses comprise a large portion of the human genome, and their upregulation can lead to induction of innate immune signaling pathways. Our objective is to understand how genome organizing proteins regulate this signaling, with the ultimate goal of identifying new pathways that can be targeted to promote cancer cell death and/or prevent autoinflammatory disease pathogenesis. Our lab is R01 funded, we have been very successful in obtaining federal and private, independent funding for postdocs, and we are excited to add passionate, motivated and creative scientists to our group.

　　Principal Investigator: Michelle Longworth, PhD

　　Lerner Research Institute Department: Inflammation & Immunity

　　Lab Research Topics:

　　Innate immunity

　　Endogenous retroviruses

　　Retrotransposons

　　Chromatin and epigenetics

　　Promotion of cancer cell death

　　For more information about the lab's research, please visit: longworthlab.com or contact Dr. Longworth at [email protected] .

　　Job Responsibilities :

　　Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation

　　Designing and conducting experiments; analyzing results

　　Writing scientific manuscripts

　　Writing fellowships

　　Attending national and international scientific conferences

　　Education:

　　PhD or MD/PhD required

　　MD with relevant laboratory experience may substitute for PhD

　　Languages:

　　English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa statusWork Experience:

　　Previous experience in a research or academic setting. Graduate student experience meets this requirement.

　　Scientific writing experience

　　Additional Preferred Qualities:

　　Experience with any of the following:

　　Retrotransposable elements

　　Innate immune signaling

　　CUT&RUN, RNA-seq, scRNA-seq, chromatin confirmation capture techniques

　　CRISPR/ Cas9

　　Physical Requirements:

　　Ability to perform work in a stationary position for extended periods

　　Ability to operate a computer and other office equipment

　　Ability to communicate and exchange accurate information

　　Ability to distinguish color

　　Manual dexterity to handle specimens and repair equipment

　　Ability to lift and transport equipment or specimens weighing up to 20 pounds

　　May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

　　Personal Protective Equipment:

　　PPE per institutional requirements; may vary by laboratoryPreferred Application Materials:

　　CV

　　Short description of thesis work (1-2 paragraphs)

　　List of 3 references

　　All application materials should be submitted directly via email to Michelle Longworth at [email protected] .

　　Keywords: Postdoc, Research, LRI, Immunology, Cancer, Virus, Retrovirus, Epigenetics, Chromatin, Innate immunity, Signaling

　　Pay Range

　　Minimum hourly: $0.01

　　Maximum hourly: $333,340.26

　　The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision and retirement.

　　Cleveland Clinic Health System is pleased to be an equal employment employer: Women / Minorities / Veterans / Individuals with Disabilities