Head of Translational and Precision Medicine - Immunology

　　Date: Jan 16, 2024

　　Location:

　　Parsippany, United States, New Jersey, 07005

　　Company: Teva Pharmaceuticals

　　Job Id: 53560

　　Who we are

　　Together, we’re on a mission to make good health more affordable and accessible, to help millions around the world enjoy healthier lives. It’s a mission that bonds our people across nearly 60 countries and a rich, diverse variety of nationalities and backgrounds. Working here means working with the world’s leading manufacturer of generic medicines, and the proud producer of many of the products on the World Health Organization’s Essential Medicines List. Today, at least 200 million people around the world take one of our medicines every single day. An amazing number, but we’re always looking for new ways to continue making a difference, and new people to make a difference with.

　　The opportunity

　　Teva's R&D Global Early Clinical Development is hiring for a Senior Translational & Precision Medicine Leader (STPML) – Immunology in the Translational and Precision Medicine (TPM) group who will be accountable for the development and implementation of the overarching TPM strategy and deployment of innovative research approaches to enhance the probability of success of drug asset programs in the Immunology therapeutic areas (TA).

　　The STPML will lead a matrix TPM Immunology TA Team and oversee testing of translational science hypothesis, generation of decisional evidence and insights, development of clinical biomarkers, as well as experimental and precision clinical development. This role will work in close collaboration with various discovery, preclinical and clinical development functions to identify opportunities for enhancing the selection of new drug candidates and for the candidates to move quickly into the late stage of clinical development.

　　Travel Requirements: Approximately 10-20% - presentations and/or attendance at 2 or more domestic and/or 1 or more domestic + 1 international scientific association meeting per year, plus key opinion leaders, scientific advisory boards regulatory meetings, academic collaborations, consortia, and other strategic meetings as required.

　　How you’ll spend your day

　　The Senior Translational & Precision Medicine Leader (STPML) oversees the provision of the TPM support to drug asset programs by enhancing the probability of success and de-risking the development of candidates in all phases of clinical development from first in human (FIH) through post-approval.

　　The STPML is accountable for the development and execution of the overarching TPM Strategy for the Immunology TA drug asset portfolio in accordance with Teva priorities.

　　Leads a matrix TPM Immunology TA Team consisting of Translational Science, Clinical Biomarker, and Precision Medicine scientists and physicians. Ensures regular portfolio reviews, proactively identifies issues, obstacles, and challenges, and develops contingency plans.

　　Oversees generation and evaluation of scientific and clinical insights that contribute to the characterization of the drug target, guide indication selection, identify targeted patient populations, support rational drug combinations, and inform mechanisms of action and resistance.

　　Oversees biomarker development and research initiatives, including association of molecular, histologic, radiographic, physiologic, and digital biomarkers with drug response, safety and/or compliance.

　　Oversees the design, planning, execution, medical monitoring, and interpretation of Experimental and Precision Medicine clinical studies (including Phase 0, Phase 1b, proof of activity and concept, adaptive, master protocol, and window of opportunity studies) and ensures that clinical studies are conducted with scientific rigor, comply with the highest ethical and safety standards and are compliant with clinical, ICH and GCP guidelines, and Teva’s SOPs.

　　Oversees identification and validation of novel endpoints for early decision making and patient or target population stratification strategies to support rapid demonstration of safety and efficacy (surrogate biomarkers, intermediate clinical endpoints, digital COAs).

　　Oversees design of experiments and studies, analysis and interpretation of data, writing of study reports, summary of key findings, and communication of insights and recommendations to the Immunology TA leadership and relevant R&D functions.

　　Oversees TPM regulatory engagements and submissions and interacts with regulatory inspectors and auditors.

　　Collaborates with various discovery, preclinical and clinical development functions to identify opportunities for enhancing the selection of new drug candidates and for the candidates to move quickly into the late stage of clinical development.

　　As a member of the TA Strategy Team (TAST), provides input and shapes the Innovative Medicine strategy for Immunology.

　　Advises Immunology TA leadership and other relevant R&D functions as an expert in all TPM related aspects of science, medicine, regulatory strategy, intellectual property (IP), commercial value, etc.

　　Provides expert support to the evaluation of in-licensing and collaboration opportunities.

　　Develops the TPM Scientific Engagement and Publication Strategy and oversees the preparation of presentations, abstracts, and scientific publications. Presents at international conferences and to internal and external audiences.

　　Fosters collaborative relationships and leads discussions with external subject matter experts, academic collaborators, patient advocacy groups, and commercial suppliers and vendors.

　　Your experience and qualifications

　　Education Required:

　　M.D. or M.D./Ph.D. from an accredited medical school with training in Pharmacology, Molecular Biology, Biochemistry, Genetics or Related DisciplinesExperience Required:

　　Minimum 7 years of early clinical research and drug development experience, experience in translational and precision medicine research and biomarker sciences.

　　Minimum 2 years of management experience

　　Experience Preferred:

　　Relevant experience in pharmaceutical/biotech or related industries.

　　Technical knowledge, clinical training, board eligibility/certification in immunology – dermatology, rheumatology, gastroenterology, pulmonology, allergology.

　　Early clinical development experience (designing/managing clinical studies, ICH, GCP, GLP)

　　Experience with regulatory interactions.

　　Project and people management, and leadership experience.

　　Functional Knowledge:

　　Company/Industry Related Knowledge: Publication record or industry experience in fields associated with translational science, precision medicine, clinical biomarkers, and early clinical development.Enjoy a more rewarding choice

　　We offer a competitive benefits package, including Medical, Dental, Vision, and Prescription coverage starting on the first day. We also offer Disability and Life Insurance, Paid Time Off, 13 paid Holidays, 6% match on the 401(k), Employee Stock Purchase Plan, and Tuition Assistance.

　　Make a difference with Teva Pharmaceuticals

　　Already Working @TEVA?

　　If you are a current Teva employee, please apply using the internal career site available on "Employee Central". By doing so, your application will be treated with priority. You will also be able to see opportunities that are open exclusively to Teva employees. Use the following link to search and apply:Internal Career Site (https://performancemanager.successfactors.eu/sf/careers/jobsearch?bplte_company=1080030P)

　　The internal career site is available from your home network as well. If you have trouble accessing your EC account, please contact your local HR/IT partner.

　　Teva’s Equal Employment Opportunity Commitment

　　Teva Pharmaceuticals is committed to equal opportunity in employment. It is Teva's global policy that equal employment opportunity be provided without regard to age, race, creed, color, religion, sex, disability, pregnancy, medical condition, sexual orientation, gender identity or expression, ancestry, veteran status, national or ethnic origin or any other legally recognized status entitled to protection under applicable laws. We are committed to a diverse and inclusive workplace for all. If you are contacted for a job opportunity, please advise us of any accommodations needed to support you throughout the recruitment and selection process. All accommodation information provided will be treated as confidential and used only for the purpose of providing an accessible candidate experience.

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　　EOE including disability/veteran