JOB REQUIREMENTS: Job Summary: The Department of Biomolecular Chemistryis a part of the School of Medicine and Public Health. Its researchfocuses on understanding the molecular underpinnings of biologicalprocesses, particularly as it relates to human disease. Research in thedepartment spans a broad range of questions and methodologies, includingDNA replication, chromatin structure, gene expression, protein andmembrane trafficking, cell signaling and metabolism, cancer,embryogenesis, and pathogenesis. The department is housed within theHector Deluca Biochemical Sciences complex, a state-of-the-art researchand instructional complex located on Henry Mall, and has a reputationfor carrying out federally funded, high level, competitive biomedicalresearch. Visit https://bmolchem.wisc.edu/ to learn more. The EnginLaboratory within the Department of Biomolecular Chemistry (BMC) isfocused on understanding how cellular stress response and organelledysfunction plays a role in beta cell physiology and pathology. Currentprojects involve studying molecular mechanisms of cellular stressresponses in pancreatic beta cells in autoimmune diabetes,ER-mitochondria communication, lysosome dysfunction, cellular senescenceand the crosstalk between stressed beta cells and immune cells. The workinvolves working with the beta cell or immune cell-specific mouse modelsof the unfolded protein response pathway and mechanistic studies usingcell culture (primary mouse and human islets), biochemical andimmunological assays (Engin et al., Sci Transl Med 2013, Lee et al, CellMetab 2020, Chen, et al., Nat Comm 2022). More information about ourresearch and publications can be found at enginlab.org. The ResearchScientist will play key roles in identifying research problems anddeveloping research methodologies and procedures, implementing in vitroand in vivo experiments and training students. The Scientist will workon understanding the endoplasmic reticulum stress in beta cells ofgenetically engineered mouse and human islets. ER-mitochondria crosstalkand senescence will also be investigated in these models. Betacell-immune cell communication and well as immune cell cellularstress... For full info follow application link. The University ofWisconsin-Madison is an Equal Opportunity and Affirmative ActionEmployer. Qualified applicants will receive consideration for employmentwithout regard to, including but not limited to, race, color, religion,sex, sexual orientation, gender identity, national origin, age,pregnancy, disability, or status as a protected veteran and other basesas defined by federal regulations and UW System policies. We promoteexcellence through diversity and encourage all qualified individuals toapply. If you need to request an accommodation because of a disability,you can find information about how to make a request at the followingwebsite:https://employeedisabilities.wisc.edu/disability-accommodation-information-for-applicants/***** APPLICATION INSTRUCTIONS: Apply Online:ipc.us/t/2ADBE0EBBD8340F4