Key Responsibilities

　　AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background and expertise with in vitro models, drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis and ability to spot, ideate and drive cutting-edge science. Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working primarily in a laboratory, the position will involve the conduct and contribution to scientific leadership of in vitro assays as well as applying translational modeling concepts to help drive the global in vitro ADME strategy at AbbVie. The candidate will be expected to qualify, confirm and evaluate new technologies as well as execute operational activities to support the mechanistic and translational understanding of early and late-stage small molecules to help advance drug candidates in our pipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience and expertise warrants.

　　Core responsibilities include:

　　Evaluating novel in vitro tools and methods, and apply established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential

　　As needed, liaise with QTAS, discovery biology/pharmacology to generate data and knowledge supporting the build-up of translational, mechanistic models

　　Communicate internally and externally on topics related to in vitro drug metabolism

　　Keep up to date with emerging literature and science in modeling and in vitro approaches.

　　Basic Qualifications:

　　PhD degree Biological/Pharmaceutical Sciences/Chemistry or related field with 0 to 5 years of relevant ADME pharma/biotech industry experience; or a Bachelor’s/Master’s degree with > 10 years’ experience with in vitro ADME experiments and DMPK projects, through academic or industry work.

　　Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment

　　Strong and relevant publication record

　　Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor

　　Passion for generating ideas, learning, solving technical problems and applying new technologies to further scientific goals.

　　Key Leadership Competencies:

　　Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance

　　Ability to inspire and lead others in areas of your expertise

　　Learns fast, grasps the "essence" and can change course quickly where indicated

　　Raises the bar and is never satisfied with the status quo

　　Creates a learning environment, open to suggestions and experimentation for improvement

　　Embraces the ideas of others, nurtures innovation and manages innovation to reality

　　Additional Information

　　AbbVie is an Equal Employment Opportunity employer: At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic. Significant Work Activities and Conditions: Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)

　　Travel: No

　　AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.