Our Team:

　　The Non-Viral Gene Therapy (NVGT) group within the Genomic Medicine Unit (GMU) of Sanofi creates innovative drug delivery modalities for treating genetic disease. The NVGT group specifically is responsible for designing, formulating, analyzing, and assessing efficacy of lipid nanoparticle (LNP) based therapeutics.

　　Job Description:

　　Sanofi is seeking a highly motivated Scientist to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in the formulation of lipid nanoparticles, with significant understanding of nanoparticle characterization methods and instruments, as well as protein engineering workflows.

　　Responsibilities:

　　Execute lipid nanoparticle formulation and characterization.

　　Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues.

　　Perform downstream analytical assays such as SDS-PAGE, ELISA, SEC, RP-HPLC, DSF, SPR, or BLI.

　　Perform incorporation of targeting antibody into LNPs and execute associated analytical assays.

　　Perform data analyses, write protocols, author development technical reports, contribute to regulatory findings, and provide internal and external presentations.

　　Plan resources for supported projects to ensure timely delivery of department objectives.

　　Collaborate with team to identify areas for improved product excellence and increase process understanding.

　　Mentor and support junior staff and build a culture of support and collaboration.

　　Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability.

　　Requirements:

　　Ph.D. in Chemistry, Chemical Engineering, Biological Engineering, or a related field with minimum 1 year of industry experience.

　　M.S. with at least 5 years of relevant industry experience or B.S. with at least 8 years of relevant industry experience.

　　Direct experience with small- and large-scale production of lipid nanoparticles for research use, ideally for both hepatic and extrahepatic delivery.

　　Direct purification experience with TFF and AKTA chromatography.

　　Experience with mRNA/DNA and LNP analytical characterization such as particle size, zeta potential, gel electrophoresis, UV-vis spectroscopy, RP-HPLC etc.

　　Experience with some or all of protein and antibody engineering workflows, ideally expression, purification, characterization, process development.

　　Preferred to have experience with bioconjugate and biorthogonal chemistry of antibody conjugates.

　　Self-motivated, organized, and detail-oriented with team leadership and mentoring experience.

　　Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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　　At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.