University of KentuckyEqual Employment Opportunity/M/F/disability/protected veteran status.Posting Details Posting Details Job TitlePost-Doctoral ScholarRequisition NumberDU11360Department Name7H025:CANCER CENTER-CORE SUPPORTWork LocationLexington, KYSalary Range$56,484 - $63,852 (dependent upon years of svc)Type of PositionTemporaryPosition Time Status Full-TimeRequired EducationPhD or equivalent in Microbiology or related fieldRequired Related ExperienceMolecular Biology RESEARCH: Cell culture, animal work, western blot, qPCR, IHC, ELISARequired License/Registration/CertificationNonePhysical RequirementsSitting at computer work station for long periods of time, Standing for long periods of time, Repetitive motion, Hazardous Chemicals or fumes, Burns/Cuts/PuncturesShiftMonday - Friday 8a-5p, occasional overtime, some weekends requiredJob SummaryThe Markey Cancer Center is seeking a Post-Doctoral Scholar. We have established the importance of neurotensin (NT), a gut hormone peptide, in obese development and its associated metabolic disorders. Obesity is associated with an increase in colorectal cancer (CRC) incidence. We also found that NT regulates intestinal epithelial cells as well as intestinal stem cells (ISC) in a manner dependent on the availability of nutrients. Under nutrient-rich conditions, NT promotes crypt cell proliferation. Under conditions of nutrient depletion, NT enhances ISC function. Obesity may rise intestinal carcinogenesis by increasing Intestinal ISC/progenitor’s population, stemness, and niche. We will investigate whether NT regulates CRC carcinogenesis via ISC or their niche. In addition, we are also interested in studying whether NT regulates CRC stem cells (CSCs). The new postdoc. will perform the in vitro experiments including cell culture, western blot, qPCR, IHC or ELISA. He/or she will perform intestinal crypt isolation and 3D organoid culture, tumor spheroid culture from patients. He/or she will also work with mice, such as sacrificing mice and collecting tissues. This position will have the potential for a fully on-site work arrangement. IMPORTANT: Resumes and CVs cannot be substituted for a completed application. Incomplete applications could disqualify you from being considered for this position. If the information on your resume is not entered on the application, this will prevent us from being able to assess your education and experience when trying to determine a salary offer. To be considered you must fully complete the online application being sure to only put one (1) job title for each entry (multiple job titles for one employer must have separate entries), the # of hours worked per week and your ending salary. You will also be required to upload a Cover Letter, CV, PhD transcript and as specific request 1, a copy of your PhD diploma. Optionally, you can upload a writing sample. To view our exceptional benefits, please visit https://www.uky.edu/hr/benefits - https://www.uky.edu/hr/benefits.Skills / Knowledge / AbilitiesMicrosoft Word, Excel, PowerPoint, Adobe photoshop, EndnoteDoes this position have supervisory responsibilities? NoPreferred Education/ExperienceWork experience in Molecular biology.Deadline to Apply03/31/2024University Community of InclusionThe University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all - identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus. As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities.Any candidate offered a position may be required to pass pre-employment screenings as mandated by University of Kentucky Human Resources. These screenings may include a national check and/or drug screen.Posting Specific QuestionsRequired fields are indicated with an asterisk (*).Applicant DocumentsRequired Documents1. Curriculum Vita2. Writing Sample3. Academic Transcript4. Specific Request 1Optional Documents Apply Here: https://www.click2apply.net/yyxMKluw7odlNsNeQUGG7jPI235554841